Evaluation of the oxidative state of women with breast cancer in AL-Hilla city

Abstract

This study aims to know the changes that occur in some biochemical standards and oxidative stresses in patients with breast cancer, because of its importance in helping the medical team to provide appropriate care for patients. The study included 40 breast cancer patients who reviewed Murjan General Teaching Hospital for the period from October 2014 to February 2015, as well as 15 women together (the control group). All samples were divided into five groups according to the number of doses (before the first dose, after the third dose, after the fifth dose, after the sixth dose and the last group after the eight dose). The levels of Catalase, Superoxide dismutase and Malondialdehyde were measured in the serum of all patients and healthy subjects using immunological and chromatic methods. The results of the current study showed a significant decrease in the effectiveness of the SOD enzyme (2.01 ± 0.18, 1.84 ± 0.62, 1.68 ± 0.28, 1.47 ± 0.44, 1.46 ± 0.43) compared to the control group (2.5 ± 0.73). The results also showed a significant decrease in the effectiveness of the CAT enzyme in patients (7.5 ± 0.5, 5.95 ± 1.65, 5.22 ± 1.2, 4.64 ± 0.5, 4.59 ± 1.6) compared to the control group (7.9 ± 2.3) in addition to a significant increase in the concentration of Malondialdehyde (MDA) in women with breast cancer during different stages of chemotherapy (2.68 ± 0.1, 3.01 ± 0.21, 3.5 ± 0.39, 4.26 ± 0.06, 4.64 ± 0.27) compared to the control group (2.5 ± 0.7). These changes that occur in breast cancer patients, especially after chemotherapy, must be taken into consideration, especially when patients are given anti-cancer drugs or any other drugs because these changes may affect the effectiveness and toxicity of these drugs at the same time.