The Correlation of E‑cadherin Expression with the Modified Gleason Score and the Grade Group of Prostatic Adenocarcinoma

Abstract

Background: E‑cadherin is a cell adhesion molecule, its downregulation is associated with poorly differentiated tumors in many organs, and its loss is associated with adverse behavior of many tumors. Objectives: This study aims to find a correlation between E‑cadherin status, the Grade Group, and the modified Gleason score in core biopsies obtained from prostatic carcinoma. Materials and Methods: This study is a retrospective and prospective cross‑sectional study that was conducted on (50) paraffin blocks obtained from core biopsies of prostatic carcinoma. E‑cadherin status was correlated with the Grade Group and the modified Gleason score. The E‑cadherin staining pattern was also examined for its correlation with perineural invasion. Chi‑square was used to determine the correlation between E‑cadherin staining pattern on the one hand and the modified Gleason score, Grade Group, and perineural invasion on the other hand and P < 0.5% was considered as significant. Results: Only six patients (12%) fall in Grade Group 1 and according to the modified Gleason score, most patients had high scores. Regarding E‑cadherin expression, 24 cases (48%) had aberrant E‑cadherin expression, while the rest 26 cases (52%) had a complete strong membranous expression. Statistically, there was a significant correlation between aberrant E‑cadherin expression and increasing grade according to the modified Gleason score and Grade Group with P values of 0.032% and 0.022%, respectively. In 24 patients (48%), perineural invasion was detected half of them had aberrant E‑cadherin expression which was statistically notsignificant when both the parameters (perineural invasion and aberrant E‑cadherin expression) are tested against the modified Gleason score and the Grade Group (P = 0.71%). Conclusion: Aberrant E‑cadherin expression is associated with increasing modified Gleason score and Grade Group but has no significant correlation with perineural invasion.