Role of Lepidium sativum in Treating Diabetes and Managing Bodily Functions’ Disorders in Rats

Abstract

Lepidium sativum seed (LS) is a plant used globally for its medicinal effect in treating diabetes. Thisstudy examined the ability of an aqueous extract of LS to treat diabetes and manage disorders of bodilyfunctions. It used 70 male Wistar rats, each weighing between 190 g and 200 g. Diabetes was establishedin the rats by injecting them with Alloxan Solution at 150 mg/kg of body weight. The rats were considereddiabetic if, after 24 hours, their blood glucose levels were higher than 180 mg/dl. Diabetes caused severealterations in their blood serum glucose (376.608 mg/dl); their kidney functions (84.512 mg/dl for urea,4.716 mg/dl for uric acid, and 0.376 mg/dl for creatinine); their liver functions (46.150 U/L for ALT, 45.654U/L for AST, 5.431 U/L for albumin, and 7.611 U/L for globulin); and their lipid profile (79.123 mg/dl fortriglycerides, 121.113 mg/dl for total cholesterol, 62.776 mg/dl for LDL, and 27.453 mg/dl for HDL). Thefindings suggest that it is beneficial to use LS to treat and manage disorders of bodily functions in rats.