The effect of ascorbic acid on peak expiratory flow rate, lipid profile & oxidative stress of asthmatic patients

Abstract

This study has been performed to evaluate the role of vitamin C as an antioxidant in the treatment of bronchial asthma in adult patients. The specific objectives of this study are to evaluate the therapeutic effect of vitamin C in the treatment of bronchial asthma in adult patients. Thirty asthmatic patients were participated in this study. The study was conducted in Sammarra drug factory from the first of November 2008 till the beginning of April of 2009. Their ages ranges between 18 to 45 years. The patients were received vitamin C (tablet of 500mg / day) for 2 months duration. The results revealed that; there was a significant increase in peak expiratory flow rate after treatment with vitamin C, as compare with before treatment. Also a highly significant decrease in serum malondialdehyde was recorded after treatment with vitamin C. Also, there is significant increase in the value of serum glutathione after one month of treatment with vitamin C (119 ± 4.7) comparing with before treatment (115 ± 8.0), & there is a 3.4% gain in serum glutathione after treatment with ascorbic acid. However, there is significant reduction in the value of serum cholesterol after one month of treatment with vitamin C (173 ± 11.2) comparing with before treatment (185 ± 7.7), & there is a 6% reduction. Moreover, there is a significant reduction in the value of triglycerides after treatment with ascorbic acid (125 ± 15.7) comparing with before treatment (148 ± 21), with a 15.5% reduction in the value of serum triglyceride. There is significant reduction in the value of serum LDL after one month of treatment with vitamin C (116 ± 8.9) comparing with before treatment (132 ± 7.7), & there is a 12.1% reduction in the serum of LDL after treatment with ascorbic acid. There is significant increase in the value of serum HDL after one month of treatment with vitamin C (33 ± 1.8) comparing with before treatment (27 ± 1.3), & there is a 22.2% gain in serum HDL after treatment.