The role of some antioxidents in treatment of adultbronchial asthma

Abstract

This study has been performed to evaluate the role of antioxidants in the treatment of
bronchial asthma in adult patients. The specific objectives of this study are to evaluate
the therapeutic effect of antioxidants in the treatment of branchial asthma in adult
patients and whether the proper supplementation of antioxidants decreases the
exacerbation of asthmatic attack. This study was conducted during the period from
February through December 2008. Eighty asthmatic patients were included in this
study. The patients were classified into 2 groups; first group was treated with vitamin
E (tablet of 400 units per day) for 2 months duration, and those include 40 patients
(24 males and l6 females), they have been subdivided according to the severity into
mild asthma (28 patients) and moderate asthma (12 patients), while the other group of
patients was treated with vitamin E (tablet of 400 units per day) and selenium (tablet
100 pg two times daily after meal) for 2 rnonths, and those include 40 patients (27
males and 13 females), and they have been subdivided according to the severity into
mild asthma (29 patients) and moderate asthma (11 patients). The results revealed a
significant inerease in peak expiratory flow rate (560.25 liter/min)after treatment with
vitamin E, than before treatment with vitamin E(524.5 liter/min), while a highly
significant decrease in serum rnalclndialdehyde was recorded after treatment with
vitamin E(2.98 nmollml) than before treatment with vitamin E (3.85 nmol/ml). There
was significant increase in peak expiratory flow rate after treatment with vitamin E
and selenium (567,25 liter/min) than before treatment (558.0 liter/rnin), serum
rnalondialdehyde shows a highly significant decrease after treatment with vitamin E
and selenium (1.60 nmol/ml) than befcrre treatment (3.67 nmollml). The results also
reveals a clinical improvement in those patients who received vitamin E and
seleniurn, because vitamin E and selenium are a better antioxidant than vitamin E
alone, and this proved by a lower serum malondialdehyde level in patients who had
been received vitamin E and selenium.