Effect of phenolic compounds Extraction of Green tea (Camellia sinsis. L) On the Glutathione of Alloxan Experimental InducedDiabeticRabbit.

Abstract

Diabetes Mellitus ;, considered u; a member of oxtdutie stress syndrome. It is
ns><><:iated with an imbalance b<:tween types of free radica ls and scavenger's system.
lllis stud> showed the effect of the polyphcnol compound~ extracted from green teu
(Camellia Sinesis L.) on alloxan induced diabetic l"dbbils to detennine their role in
treaunent of diabete> mellitus. their effect on enzymatic antioxidant and to kno" the
histological effects on the diabetic kidney. The rabbits group was divided into fhe
groups. each group consist of I 0 rabbits. The blood and thsue samples from these
aroups "e"' taken for anal) si< and the result ere a, follo"':There was a $ignificanr
increase in Glucose "hen pol)p/lenol extract of green tea.,., used ga~ a significant
dc"eig1.200mg/kg of bod) "eight as compared "it~ din betic group. There was a
significant decrease in glutathione. When polyphenul extract of green tea wa!> used
with do~c rate 100mg /kg of bod) weight ga'e a signit1cnnt increase (p<0.05) in all
parameters a.~ compared with diabetic group. In comparison between the efficacy of
herbs polyphenol compound in gt·cen tea, glibcneclamide ,it was appeared that the
herbs are the bener based on crficacy on treatment of diabetes and their effect on
glucose and glutathione. fhe present results revealed that alloxan "'as effectively
induced diabetes b} partial de,truction of 1>-cells of pancreas "hich lead to elevation
of blood glucose lc•1:l. A• a consequence of h)pel'@lycemia the abnonnal effect 8<
obvious in certain tis.lh,tological ime>tigattOJ> sho"s that all the lesions in the kidney that result from
diJb<:tes >Uch as h)pertroph), degeneration and h}lano,is of the glomeruli.