Hodgkin’s lymphoma of the childhood: Experience of single hemato‑oncology center

Abstract

BACKGROUND: Hodgkin’s lymphoma (HL) is a malignant lymphoma that accounts for approximately7% of childhood cancers. The incidence of HL in childhood varies by age; it is the most commonchildhood cancer in the age group of 15–19 years.OBJECTIVE: The objective of the study is to determine the clinical presentation and outcome of HLamong children under 15 years of age.PATIENTS AND METHODS: A retrospective study carried out at the hemato‑oncology department ofchild’s central teaching hospital included 46 HL patients under 15 years of age who were diagnosedover 6 years from January 2010 to December 2015. Demographic characteristics, histopathologicaland clinical features, treatment modalities, response to treatment, and outcome were obtained fromthe records files of the patients.RESULTS: Among a total of 46 children with HL, there were 33 (71.7%) males and 13 (28.3%) females;the male‑to‑female ratio was 2.1:1; the mean age of this study was 8.3 years. Lymphadenopathy wasthe most common sign, with cervical lymph node being the most common primary site of involvement.47.8% of the atients present with Stage II, and the mixed cellularity histopathological subtypes were thecommon recognized subtype. Event‑free survival (EFS) is 78.3%, and overall survival (OS) was 95.5%.CONCLUSION: Two‑year OS (95.5%) and EFS (78.3%) of the HL patients were accepted ascompared to other studies