Role of Flavonoinds From Nigella sativum seeds in Decreasing the Effect of Hydrogen Peroxide on ECG in Adult Male Rabbits

Abstract

This experiment was carried out to evaluate the role of flavonoinds of Nigella sativum seeds to reduce the effect of hydrogen peroxide on electrocardiography in rabbits. Eighteen adult male rabbits were divided into three equal groups (6group) and were treated for six weeks as follows: first group (control), which were given ordinary tap water, second treated group (T1), animals in this group given 0.5%H2O2 in drinking water and third treated group (T2) was handled as in T1 plus oral intubation of flavonoinds (27.5mgKg B.W). Electrocardiography was recordings from rabbits after 3 and 6 weeks of treatment. The results conducted that H2O2 treated group (T1) showed significant increased in P-R interval, R-voltage and significant decreased in T-wave voltage and heart beats. While treatment of animals with flavonoinds of Nigella sativum seeds caused significant decrease in P-R interval and R-voltage with an increase in T-wave voltage and heart beats, direct to ward their control levels. It was concluded that the flavonoinds of Nigella sativum can ameliorate the deleterious effects of hydrogen peroxide on electrocardiography .More studies are needed to convince these findings.

Keywords

P-wave, ECG, H2O2, flavonoids