The relationship between uric acid and dyslipidemia in type 2 diabetic patients with urolithiasis


Background and objectives: Type 2 diabetes mellitus (DM) is characterized by insulin resistance, which can increase the risk of kidney stone formation. This study aimed to find out the association between serum levels of uric acid and lipid profile in type 2 DM patients with urolithiasis in comparison to those without. Methods: This cross-sectional study was conducted with the approval of the institutional ethical review committee for human studies. A total of 60 type 2 DM patients were included in the study and grouped as patients with urolithiasis and patients without urolithiasis. Biochemical parameters studied were glucose, urea, creatinine, uric acid, serum uric acid to creatinine ratio, lipid profile, HbA1c, and triglyceride glucose index as a measure of insulin resistance. Results: A significant increase was found in uric acid, urea, serum uric acid to creatinine ratio, and triglyceride glucose index level in type 2 DM urolithiasis cases as compared to DM cases without urolithiasis. It was also found that total cholesterol, triglycerides, LDL-cholesterol, and VLDL-cholesterol levels were significantly elevated and HDL-cholesterol was significantly decreased in urolithiasis cases. Serum uric acid level was positively correlated with total cholesterol, triglycerides, LDL-cholesterol, and VLDL- cholesterol and negatively correlated with HDL-cholesterol in diabetics with urolithiasis. Conclusions: From this study, it is demonstrated that urolithiasis patients with type 2 DM have higher insulin resistance, altered lipoprotein metabolism, and an increased level of serum uric acid compared to type 2 diabetics without urolithiasis and their lipid components are strongly associated with increased serum uric acid.