Polymeric micelle improves the bioavailability of low water-soluble phytochemicals

Abstract

Nanocarriers serve a crucial function in improving the delivery of insoluble and poorly penetrating drugs. Inorganic, lipidic, peptide-based, or virus-like nanocarriers and polymeric nanoparticles are categories of nanoscale materials. In this article, we emphasized on polymeric nanosystems, with micelles as the primary focus. These compounds improve the solubilization, stability, and bioavailability of hydrophobic drugs. Natural or synthetic polymers are utilized to construct polymeric nano-systems. Polymeric Micelles are often composed of amphiphilic di- or tri-block copolymers that contain both hydrophilic and hydrophobic components. They have the ability to self-aggregate. Below a critical micellar concentration, also known as CMC, these polymers persist in solution as free molecules; however, as they exceed CMC, they start to selfassemble into micelles with a hydrophilic shell enclosing a lipophilic core. Shape, size, thermodynamic and kinetic stability, surface qualities, and the capacity to internalize cells are all areas in which they excel. Pluronic F127 is an impressive polymeric micelle used to enhance the delivery of poorly soluble drugs. It enhances the solubility, stability, bioavailability, target selectivity, and bioactivities of a number of phytochemicals, such as berberine, resveratrol, and curcumin, in aqueous settings. Pluronic F-127 is a biocompatible micelle that has shown promise as a drug delivery tool for the research and development of delivery systems for poorly watersoluble therapeutics.