Estimation of renin and D-dimer levels in women with polycystic ovary disease with or without coronavirus infection


Background and objective: Polycystic ovarian syndrome (PCOS) is a common endocrinological disorder among women of childbearing age. Coronavirus disease 2019 (COVID-19) is an acute respiratory disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The association between PCOS and COVID is yet to be understood. This study aimed to determine the levels of renin, D-dimer, and some relevant biomarkers in patients with PCOS (with and without COVID-19). Methods: This cross-sectional study included 120 women [80 PCOS women (40 with COVID-19 and 40 without COVID-19) and 40 non-PCOS women (20 with COVID-19 and 20 without)] with age range of 15–40 years old. Blood samples were collected from participants, and biochemical parameters were evaluated by ELISA (renin and D-dimer), VIDAS (sex hormones: LH, FSH and testosterone), and colorimetric methods (serum lipids and glucose concentrations). Results: Renin and D-dimer levels were significantly higher in PCOS groups compared to non-PCOS groups. In addition, luteinizing hormone, fasting blood glucose, and serum lipid tests (total cholesterol, triglycerides, and low-density lipoprotein) reveal significant elevation in PCOS patients compared to non-PCOS women. While, high-density lipoprotein and follicle-stimulating hormone levels were lower in PCOS patients. The results also showed that a highly significant increase in renin and D-dimer levels can be seen in PCOS patients with COVID-19. Conclusions: In the present study, we found there is a possible relationship between renin and D-dimer in PCOS patients and SARS-CoV-2 infection.