Abstract

The biology department's animal house in college of sciences at Iraq's AL-Qadisiyah University hosted this study. It's part of Iraq's AL-Qadisiyah University, to demonstrate that the kidneys and Liver were subjected to oxidative stress from reactive oxygen species, which led to harmful consequences of the indomethacin medication on the body and the weight of the organs. 40 male Wister rats, aged (2 -3 ) months, weighing between 200 and 300 grams. Four groups of 10 rats. Control, 5 mg/kg, 7 mg/kg, and 10 mg/kg of indomethacin were given for 21 days to the groups.After the experiment, the animals were killed. The results demonstrated a substantial rise in body weight (p<0.05) in all groups following the experiment compared to the initial weight, although a significant reduction in body weight (p<0.05) in each of the groups that received the 5 mg/kg, 7 mg/kg, and 10 mg/kg treatments compared to the control group during the course of 21 days. When compared to the rats in the control group, the relative liver mass of the rats that were administered doses of indomethacin at dosages of 5, 7, and 10 mg/kg rose considerably (p< 0.05). The group that received 10 mg/kg saw the greatest percentage rise. The control group and those receiving 5, 7, or 10 mg/kg indomethacin had similar kidney weights (p< 0.05). In conclusion, indomethacin causes an increase in body weight, increase in liver weight, but the kidney weight remained the same.

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The article was added to IASJ on 2023-06-26

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