Abstract

Background: Eosinophil Derived Neurotoxin (EDN) has been used to assess eosinophil cells activity and to monitor inflammation in asthmatic patients.Objective: Study the correlation between Eosinophil Derived Neurotoxin (EDN) and asthma.Materials and methods: Eosinophil Derived Neurotoxin (EDN) was extracted from eosinophils taken from patients with eosinophilic leukemia.This extract was conducted to study its biological effects (Gordon phenomena) and detection of antibodies against it in urine samples of diagnosed asthmatic patients.Results: One of the two tested rabbits with the extracted EDN test material showed the signs and symptoms of Gordon phenomenon during the second day after injection and continued to show complete paralysis within the fifth day .Patients urine results showed that it contained a higher values of END than the control subjects urine .Conclusion: Results revealed that EDN is a product that can be used as a monitor for asthma.Key words: EDN, asthma, ELISA.

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The article was added to IASJ on 2012-05-21

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