Microbiological Profile of Neonatal Septicemia


ABSTRACT:BACKGROUND :Neonatal septicemia is a major cause of morbidity and mortality in developing countries.OBJECTIVE:The study is to determine the prevalence , the pattern of organisms and the mortality of neonatalsepticemia in a neonatal care unit.PATIENTS AND METHODS:All the cases of neonatal septicemia diagnosed and treated in the neonatal care unit at al-kadimiyateaching hospital for the period january-june 2010 were included in this study. The collected datawere : Gender, Birth weight, Gestational age, Onset of sepsis, Place of delivery and Outcome ofdisease.RESULTS:Out of 589 newborns admitted, 73(12.4%) were confirmed cases of neonatal septicemia. Themortality from neonatal sepsis was 16.4%.Low birth weight and prematurity were independentfactors associated with death (P value=0.004 and 0.020 respectively).There were 24 cases (32.9%)of early onset sepsis and 49 cases (67.1%) cases of late onset sepsis. The most common pathogenswere gram- negative bacilli causing early-onset sepsis (54%) and late onset sepsis (59%). Only 6cases out of the total 73 cases of neonatal septicemia were caused by staphylococus aureus (8.2%) .Over 50% of gram-negative bacilli are antibiotic resistant.CONCLUSION:The high rate of gram-negative septicemia and the antibiotic resistance to both ampicillin andgentamycin indicate that the infection was most probably nosocomial in origin.