A Comparative study of the antioxidant activities of three series of first-and second-generation PPI dendrimeres (G1 and G2) functionalized by 2- hydroxy-P-naphthoquinone

Abstract

The work presented focuses on the synthesis of molecules capable of blocking the deleterious effects of oxidative stress. Oxidative stress is caused by an imbalance between the pro-oxidant and antioxidant systems, with the former benefiting. It is implicated in numerous pathologies, either as a cause or a consequence. Oxidative stress is involved in chronic processes such as atherosclerosis and diabetes. The work presented in this article focuses firstly on the synthesis of a new class of first- and second-generation PPI (Polypropylene Imine) dendrimers (G1 and G2) functionalized with 2-hydroxy-p-naphthoquinone, and secondly on the assessment of their antioxidant activity.A study of antioxidant activity using the 1,1-diphenyl-2-picryl-hydrazyl (DPPH) method• revealed that the dendrimers synthesized have antioxidant activity. All the results obtained were interesting.