THE ACTION OF IRAQI PROPOLIS ON THESPECIFIC ACTIVITY OF ADENOSINE DEAMINASEENZYME IN ALBINO MICE

Abstract

ABSTRACT
The action of propolis in the specific activity of adenosine deaminase (ADA; EC
3.5.4.4) in albino mice was investigated. Two oral administrations (10 and 20
mg/kg/day) of Iraqi propolis extract with two control groups were used. Treatment
with propolis enhanced the specific activity of ADA enzyme in serum, thymus and
spleen as compared to control groups; the stimulation was greater at the higher
dose. While, treatment with Mitomycin C; MMC (positive control) under similar
condition caused a highly significant inhibition in activity of ADA in serum,
thymus and spleen as compared to negative control. This study indicates that Iraqi
propolis extract may potentiate immunity with the modulation of adenosinergic
system through increasing splenic and thymic ADA enzyme activity.
KeyWords: Propolis, adenosine deaminase, mitomycinC