ASSOCIATION BETWEEN TORCH AGENTS AND RECURRENT SPONTANEOUS ABORTION

Abstract

Background:Toxoplasmosis, rubella, cytomegalovirus (CMV), and herpes simplex virus (HSV) (TORCH), that can cause illness in pregnant women and may cause birth defects in their newborns. These entire infectious agents induce a shift of immune response during pregnancy from Th2 to Th1 and apoptosis which can be observed clinically as an abortion process.Objective: To find out the significance of TORCH infection in patients with recurrent spontaneous pregnancy loss.Materials and method: A total of one hundred and nineteen women, ranged from the mean age (23.9 − 28.5)years, were enrolled in the current study and were further classified into three categories: Group A- Recurrent spontaneous abortion (RSA): n= 62 women, with a mean age of (28.5 + 0.68);Group B- non- recurrent spontaneous abortion (non-RSA): n= 34 women, with a mean age of (26.4 ± 0.85)and group C- Control (successful pregnancy): n= 23 women, with a mean age of (23.9 ± 0.88). From each patient and control, blood sample was collected. Enzyme linked immune sorbent assay (ELISA),using anti CMV/IgG and IgM ,Rubrlla/IgM/IgG ,HSV/IgM and Toxoplasma/IgM/IgG was used.Results: the current study revealed a significant difference in the levels of each of Toxoplasma gondii as well as Cytomegalovirus specific circulating IgM antibodies between group A and group C (p< 0.05) based on their respective enzyme linked immuno sorbent assay (ELISA)Conclusion: In TORCH infections, there was a significant difference between RSA and control in acute infection of T.gondii and in the primary infection of CMV.Key words: Torch,Recurrent Spontanious Abortion,Elisa