SERUM LEVELS OF INTERLEUKIN-1 ALPHA AND INTERLEUKIN-6 IN ACUTE CORONARY SYNDROME PATIENTS

Abstract

BackgroundCytokines are responsible for the modulation of immunological and inflammatory processes and play a significant role in the pathogenesis of acute coronary syndrome patients (ACS).ObjectiveThis study aims to investigate the serum levels of IL-1α and IL-6 in ACS patients.MethodsThe study covered 140 subjects. It comprised a total of 101 patients with ACS patients [62 with acute myocardial infarction (AMI) and 39 with unstable angina (UA)], compared with 39 healthy individuals with no history of cardiac disease. Serum IL-1α and IL-6 analysis was performed by ELISA.ResultsThe present results revealed that there were significant elevation in mean serum levels of IL-1α and IL-6 in patients with ACS ( AMI and UA) as compared to healthy control (P<0.001). Moreover, the levels of these cytokines were significantly higher in AMI patients when compared to UA patients (P<0.001).ConclusionThese finding suggest that IL-1α and IL-6 play an important role in pathogenesis of ACS.KeywordsAcute coronary syndrome, IL-1α and IL-6.