Studies of the Effects of Metformin, Diane, and Androcur in Treatment of Infertile Women with Polycystic Ovary Syndrome in Babylon Province

Abstract

Back ground: Infertility is one of problems that affect women and one of its cause is increase androgen level specially in women with Polycystic Ovary Syndrome (PCOS).The aim is to assess the effect of metformin alone versus metformin with oral contraceptive and antiandrogen on PCO patients. Patients and method: The study was conducted in Babylon province,from the infertility center of maternity and pediatrics teaching hospital. Women with PCOS were recruited from November 2008 to April 2009. The subjects study consisted of (90) married women. (n=30) received metformin only. B.(n=30)received Metformin+ ethinyloestradiol-cyproterone acetate(Diane)+cyproterone acetate (Androcur C. Thirty women were normal, and fertile as a control group.The results: The results show that the highest incidence of PCOS among adult women occurs in age group (25-35) years and represent 58%, and 55% of patients have positive family history, and 65% of them had a history of primary infertility and high geographical distribution of PCOS occurs in urban areas .Also there is larger reduction in LH hormone in both treatment's regimes While in prolactin there is little increment Conclusion: Our study showed significant response in both groups (more in group B)that support the effect of metformin added to that of Diane together give a better response in PCO patients with moderate to sever signs of hyperandrogenism.