CYTOTOXICITY OF NON-BOUND COLICINS EXTRACTED FROM Escherichia coil ON NORMAL WHITE BLOOD CELLS AND MYELOBLAST ISOLATED FROM ACUTE MYELOID LEUKEMIA BLOOD PATIENTS

Abstract

Four types of non-bound colicins (H5, H9, H13, H19) were extracted from intestinal normal flora Escherichia coil isolated from healthy people’s stool. Then study cytotoxic effect of colicins on normal white blood cells (WBCs) from healthy people. And cytotoxicity on myeloblasts isolated from AML patients blood. Results showed, myeloblasts from AML patients were more sensitive to colicins than normal WBCs from healthy people.The toxic effect was dose-dependent and exposure time.