Relationship between Some Trace Elements, Lipid profile and Hypothyroidism


There are many questions still remain concerning the relationship betweenthe trace elements and thyroid hormones. Therefore, this study was undertakento evaluate the concentration levels of some trace elements (zinc, copper,selenium, manganese, magnesium), and to reach the possible correlationbetween these trace elements and thyroid hormones in hypothyroidism.The study was included 50 patients with hypothyroidism and 28 healthyvolunteers' serves as control group matched with age, sex, and body mass index(BMI). All participant had not taken vitamin or mineral supplements for at least2 weeks before sampling, blood sampling were drawn to determine the serumtrace elements levels (Zn, Cu, Se, Mn, and Mg), thyroid hormone (T3, T4, andTSH), and lipid profile (TC, TG, LDL, HDL, and VLDL). The results indicatethat the hypothyroidism patients have significant increase in TSH levels (P<0.01), and significant decrease in T3, T3/T4 levels (P<0.001), although, therewere decrease in serum trace elements (Se, Zn, Cu, Mn, and Mg) inhypothyroidism patients compared with controls group, (P< 0.001 for all serumSe, Zn, Cu, Mn, and P< 0.01 for Mg). The results indicate that there was nosignificant correlation between serum Cu, Mn, Mg and T3, T4, and TSH level;but, there was a significant positive correlation between Se-T3 (r=0.286,P<0.04), and Zn-T3 (r=0.3, P<0.01), also there was only a significant negativecorrelation between serum Se-TSH levels (r=-0.315, P< 0.02) in hypothyroidismpatients. There is significant increase in the mean serum cholesterol (TC),triglycerides (TG), and low density lipoprotein (LDL) in patients compared withnormal controls (P 0.01, P<0.001, <0.05) respectively. Also, there is significantdecrease in the mean serum concentration of high density lipoprotein (HDL) inthe patients with hypothyroidism than control, and our results showed that thereis positive correlation between TSH levels and lipid (cholesterol, triglyceride,and very low density lipoproteins), although, there is negative correlationbetween Mg concentration and lipid (TC, TG, LDL) levels. We conclude thatthe trace elements Se, Zn, Cu, Mn, and Mg have altered in hypothyroidismpatients; there are correlations between some trace elements (Se, and Zn) andthyroid hormones, but there are no obvious correlations between the other traceelements (Cu, Mn, and Mg) status and thyroid hormones. That is means there isan interactions between some trace elements and thyroid hormones levels.