Class II Human Antigen in Iraqi patients with Hodgkin’s Lymphoma

Abstract

Objective: To detect the association between human leukocyte antigen) HLA) class II and Iraqi patients with Hodgkin’s lymphoma (hl).Subject and methods: Study groups include 80 newly diagnosed Hodgkin’s lymphoma patients and two control group patients control which include 50 patients who were newly diagnosed to be affected by non Hodgkin’s lymphoma (NHL) and healthy individuals. Antibody mediated complement dependent cytotoxicity assay was done by treating sample of patients lymphocytes with a panel of anti-HLA antisera and complement.Results: The frequency expression of hla-dr3 and DQ1 was significantly greater in Hodgkin’s lymphoma patients thanhealthy control group with (p<0.001) for HLA-DR3 and (p<0.005) for DQ1.Conclusion: Hla-dr3 and dq1 are more related with Hodgkin’s lymphoma in Iraqi Arab population that reflect HLAalleles have immunogenetic factors of predisposition to Hodgkin lymphoma