The Role of JAK2 Mutation in Polycythaemia Vera in Some Iraqi Patients


Polycythaemia vera (PV) is a myeloproliferative disease that arises in a clonal haematopoietic stem cell and ischaracterized by increased red blood cell production that is independent of the mechanisms that normally regulateerythropoiesis. Evaluation of the role of JAK2 mutation had been carried out in polycythaemia vera in some Iraqipatients, from beginning June 2008 up to the 30 of November 2009,attending national center of hematology for researchand treatment . Thirty two patients have been included with age range of 30-66years and ten apparently healthy controlgroup with age range of 32-55 years. Results revealed that polycythemic patients had mean age of (50.41 ±1.71). Themolecular study using amplification refractory mutation ,has clarified that (90.6%) of patients with polycythaemiavera had JAK2 mutation .According to the above results to introduce JAK2 mutation test as part of routine work insuspected patients with Polycythaemia vera.