Hormonal and Immunological Disturbances in Patients with Rheumatoid Arthritis and Systemic Lupus Erythematosus


ABSTRACT:BACKGROUND:Rheumatoid arthritis and systemic lupus erythematosus are multifactorial autoimmune diseases.Some recent reports indicated a hormonal disturbances affected the balance between Th1 and Th2lymphocyte response.OBJECTIVES:To investigate the immunological and hormonal disturbance in patient with rheumatoid arthritis(RA) and systemic lupus erythematosus (SLE).METHODS:Serum samples, were collected from patients with RA, SLE and control, then the tests forantinuclear antibodies, anti double strand DNA, anticardiolipin antibodies are done by usingEnzyme linked immuno assay (ELISA) method. Also, hormonal studies including estrogen,progesterone and prolactin level are done by using the Radio immunoassay technique (RIA).RESULTS:The results indicated the increasing of ANA, anti ds-DNA, and anticardiolipin antibodies. Also,elevation in the levels of estrogen, progesterone and prolactin in patients with RA and SLEcomparing with control.CONCLUSION:Immunological and hormonal disturbances in patients with RA and SLE were documented throughthrough the increasing of ANA, anti dsDNA anticardiolipin antibodies and elevation of the level ofestrogen, progesterone, and prolactin.