Synthesis and Characterization of Some New Derivatives of Heterocyclic Compounds and its Polymers with study their Biological Activity

Abstract

Three series of heterocyclic compounds were synthesized derived from 2-amino-5-styryl-1,3,4-thiadiazole[1]. The first series includes the Shiff bases(II) prepared from the reaction between 2-amino 5-styryl-1,3,4-thiadiazole(I) with different substituted benzaldehydes in presence of glacial acetic acid and absolute ethanol. Then these derivatives have transformed to its polymers(III) by using dibenzoylperoxide as initiator. The third series was prepared from the reaction of the Shiff bases and 2,3-dimethyl maleic anhydride to give oxazepine compounds(IV). The reactions was followed by TLC.,and then these identified by FTIR, UV./Vis., (1H-NMR,13C-NMR for some of them) spectra and melting points. The biologically activity for some of the prepared compounds-was--studied----against Staphylocaccus Sal. Typhi , Ps. Arugenosa and Escherichia Coli.