Synthesis of Some New Chalcone Derivatives from Application of PhaseTransfer Catalysis Technique

Abstract

A series of substituted chalcones have been prepared followed by condensation of these chalcones with some compounds containing an active methylene group (cyclohexanone) or acidic hydrogen (phenyl urea) to afford corresponding chalcones derivatives. On the other hand, a number of epoxides were prepared from the reaction of chalcones with hydrogen peroxide in alkaline media under phase transfer catalysis in (liquid-liquid) system . Physical and spectral methods were used to confirm the structures . Theoretical calculations based on the data obtained from the heat of formation (H.F) and the steric energy (S.E) were used to investigate the suggested reaction mechanism.