Novel Synthetic 3-Amino-2-Methylquinazolin-4(3H)- one (L) Induce Apoptosis and Modulate Antioxidant Enzyme Activity in Some Cancer Cell Lines


A quinazoline ring possess interesting biological activities, we study the combined cytotoxic activity, induction ofapoptosis and antioxidant enzyme modulation of new synthetic aquinazoline compound in several cancer cell lines.This compound is 3-amino-2-methylquinazolin-4(3H)-one (L), it was synthesized in the laboratories of Department ofApplied Science - University of Technology – Iraq. Its showed potent cytotoxic and growth inhibition effect on all cancercell lines tested. Cells death was due to the induction of apoptosis through modulation of superoxide dismutase (SOD),glutathione S transferase (GST) and glutathione (glutathione L-glutamyl-L-cysteinylglycine, GSH). These results indicatethat this compound has desirable drug-like properties; it’s of great significance to understand its full anti-proliferativemechanism.