Study of Serum Uric Acid in a Group of Insuline Dependant Diabetes Mellitus Iraqi Patients


ABSTRACT:BACK ROUND:The long duration of insulin dependant diabetes mellitus eventually ends with complications like renal impairment especially if it was badly controlled ,the first sign of renal involvement is the elevation of serum uric acid above or near upper normal values(1).OBJECTIVE:One hundred and thirty type1 diabetic patients were enrolled in the study, they represent a selected sample of patients who attend the Specialized Center for Endocrinology and Diabetes (Baghdad Russafa Directorate) during the period from November 2006 to April 2007 compared with forty healthy individuals as control group of similar age group.METHOD :The determination of fasting blood sugar ,uric acid and blood urea were done by enzymatic colorimetric test following the Procedure performed by manufacturers.RESULTS:The level of serum uric acid and blood urea were normal in all cases of juvenile diabetes but as the duration of the disease increases the values of the serum uric acid started to raise and could be the first sign of renal impairment in diabetic patients even before albuminuria..CONCLUSION:The concentration of uric acid in the blood is an independent marker of failing kidneys and may even play a causative role in the decline of renal function.