Viral hepatitis markers screen in children with cute Lymphoblastic Leukemia

Abstract

Background:Patients treated for pediatric malignancy are at high risk of parenterally transmittedviral hepatitis.Objectives:To detect the seroprevalence of hepatitis B and C viral infections in children withAcute Lymphoblastic Leukemia & identify some variables that could affect itsprevalence in these patients.Patients and Methods:One hundred fifty pediatric acute lymphoblastic leukemia patients, presented toChildren Welfare Teaching Hospital, Baghdad, during the period from March 11th2007 to July 31st 2007 were enrolled in this study; they were 103 males, 47 females,aged (2.25 months- 16 years). Sera of these patients were investigated for hepatitismarkers including HBsAg and Anti HCV antibody.ResultsThe majority of patients were from Baghdad 104 (69.33%). Almost all childrenreceived 3 doses of hepatitis B vaccine according to the national Iraqi vaccinationschedule & 111 (74%) of them received another course of vaccination during theiradmission to the oncology unit at CWTH.Screening for hepatitis B virus infection was positive in 54 (36%) of cases while forhepatitis C virus infection was positive in 4 (3.25%) of cases.ConclusionMultiple blood transfusions and prolonged duration of observation of patients showedsignificant statistical impact on the incidence of HBV infection.