Vitamin D2 As I{umoral Immunosuppressent in Rabbit

Abstract

Serial concentrations of vitamin D, that ranges liom 1.7-34 ru were made in 2% eggalbumin aqious solution and used for rabbit pdming ihrough multisite and o|al protocols. Meantime,same viiamin D, concentration incorporated in the diluting buffur ofthe h,?erinrmune and immuneseraofanti EA specificity and titred against egg albumin coated erythrccltes.The imnunornodulation effe€t was scored as either titre eDhancement or titer rcduction .vit.D, was found as being humorai immunosuppressant and of dose dependent type . The dose r€sponserelationship was of simple linear t)?e . Such $ppression effect was evident bolh invivo dxdng theimmune response time cuve and jnvitro on rcady made anti EA anxibody titers .The hurnoraljmmunotoxiciry parameters as NOL tircshold and activity range were determined vit. D, can be ofhelpin maintenance and t|eatment of autoimmxne disease and elafi incomDatibilitv conditions.