OXIDATIVE STRESS AND IMMUNOGLOBULIN LEVELS IN PATIENTS WITH HODGKIN'S LYMPHOMA

Abstract

ABSTRACTObjective: To assess, oxidative stress (by measuring malondialdehyde "MDA" which reflects lipid peroxidation, andtotal antioxidant status "TAS"), and immunoglobulin levels (IgA, IgG, IgM) in patients with Hodgkin's lymphomabefore and one month after starting cytotoxic drugs, in comparison with controls.Design: Case-control studySetting: This study was conducted in the Hospital of Nuclear Medicine and Department of Pharmacology, College ofMedicine, University of Mosul.Patients and Methods: Twenty-three patients with Hodgkin’s lymphoma were included in this study together with 24apparently healthy subjects taken as a control. Initially for both patients and control, serum MDA, TAS andimmunoglobulin levels (IgA, IgG, IgM) were measured and reported one month from starting specific cytotoxic drugsfor the patient groups and after one month gap period for the control using especial commercial kits from Randoxcompany (UK), for measuring TAS and immunoglobulin levels, while measurement of MDA was done by laboratorymethod.Results: Before starting cytotoxic regimen, there was a highly significant rise in serum MDA concentration inpatients with Hodgkin's lymphoma in comparison with control. After one month from starting cytotoxic regimen,there was a highly significant rise in serum MDA concentration and a significant reduction in TAS and serumimmunoglobulin levels. By comparing the period before and after starting cytotoxic regimen in patients withlymphoma, there was a significant rise in MDA and a significant reduction in TAS and immunoglobulin levels withthe exception of IgM which showed insignificant reduction.Conclusion: This study revealed a rise in the oxidative stress; to which patients with Hodgkin's lymphoma were liableto, by the effect of specific cytotoxic regimen. This is reflected by the rise in the serum level of MDA and a reductionin the TAS after cytotoxic regimen. It also indicated a reduction in immunity of such patients during cytotoxicregimen as reflected by a reduction in immunoglobulin levels.