LOCALLY MADE CHITOSAN COVALENTLY LINKED TO INDOMETHACIN: A NOVEL APPROACH TO FORMULATE SUSTAINED RELEASE INDOMETHACIN CAPSULE IN BASRAH

Abstract

ABSTRACTThe sustained release capsules are pharmaceutical dosage form used for the treatment of chronic rather than acutediseases and are useful because of its convenience and less side effects. This work describes an attempt to formulateindomethacin sustained release capsule using indomethacin covalently linked to chitosan. Chitosan was prepared byalkaline -N-deacetylation of chitin, which was isolated from the shells of local shrimps. The yield of chitosan wasfound to be 80%. This polymer was found to be white crystal, odorless and the IR spectroscopy of it was similar to astandard reference. Chitosan has been covalently linked to indomethacin and the ratio of drug to polymer was foundto be 5:1. The chemical interaction between the drug and the polymer was proved by IR studies. In vitro release atdifferent pH were performed and the release of indomethacin in the prepared sustained release capsule were testedand compared with conventional indomethacin capsule INDOMIN-25mg, and a commercial sustained release capsuleINDO-75-SR. The release of indomethacin in our product was completed within 12 hours, while the conventionalINDOMIN capsule and commercial INDO-75-SR capsule released within 2.5 and 5 hours respectively. In conclusion acheap, locally made chitosan can be used in formulation of sustained release capsules by covalently linked to drugscontaining carboxyl group (like indomethacin) or can be modified to have a carboxyl group.