Prostate Specific Antigen in Polycystic Ovary Syndrome


ABSTRACT:BACKGROUND:Polycystic ovary syndrome (PCOS) is the most common cause of hyperandrogenism, and anovulatory infertility; it affects 5-10 % of females at their reproductive age. Prostate specific antigen is a glycoprotein that is secreted from the prostate in males and from paraurethral glands and breast in female.OBJECTIVE:To evaluated the total and free prostate specific antigen levels in female with PCOS, and find out its relation with FSH, LH, Prolactin and testosterone (F,T).METHODS:Eight patients with PCOS diagnosed based on three criteria* High LH: FSH ratio; LH luteinizing hormone to FSH follicle stimulating hormone is 2:1 or more particularly in the early phase of menstrual cycle (3-6) day.* Ultrasound reveals polycystic ovaries* Biomedical hyperandrogenism. ; Elevated androgens particularly free testosterone.Forty normal fertile females served as a control group in this study .Blood samples were taken from all individuals from 3-6 day of menstrual cycle to measure total and free prostate specific antigen, total and free testosterone ( by enzyme linked immunosorbent assay) and FSH,LH, Prolactin (by Immunoradiometric assay).RESULTS:Patients with PCOS and controls differed significantly in all parameters studied, except FSH (P >0.05).LH and LH: FSH ratio were significantly elevated in PCOS group compared to normal control group (11.9±5.4 vs. 7.0±0.6) and (2.3±1.1 vs. 1.2±0.1) respectively.Total and free testosterone were significantly elevated in patient with PCOS compared to normal control group (50±9.6 vs 24 ±3.4 ) and (8.9 ±1.0 vs 1.9±0.4) respectively .Total and free PSA significantly elevated in patient with PCOS compared to normal control group (1.2±0.4 vs 0.1±0.02) and (0.04±0.01 vs 0.01±0.003) respectively.Positive correlation between T-PSA, F-PSA and T-testo, F –testoCONCLUSION:Total and free serum prostate specific antigen levels are higher in patient with PCOS.Serum PSA measurement might be marker of hyperandrogenism in females suffering from PCOS