STATUS OF LIPID PEROXIDATION BY PRODUCTS; MALONDIALDEHYDE AND URIC ACID IN DIABETES MELLITUS (TYPES 2 )AND RHEUMATOID ARTHRITIS ( A COMPARATIVE STUDY)

Abstract

ABSTRACT:The aim of the current study was to compare antioxidant defenses and oxidative stress markers in patients with Diabetes Mellitus (DM) and in those with Rheumatoid Arthritis (RA). Across-sectional study was conducted with 74 participants in two distinct groups: Diabetes Mellitus types 2, Rheumatoid Arthritis and healthy blood donors. Malondialdehyde and uric acid were compared between these groups. Uric acid was measured as antioxidant defenses tested in blood samples from (RA) and (DM), rather than the degree of lipid peroxidation was measured in term of malondialdehyde (MDA). MDA level was 3.29 ± 0.59 µmol/L in control group which was significantly lower than in diabetic and Rheumatoid arthritis patients 6.32 ± 0.84 µmol/L , 6.75 ± 0.77 µmol/L respectively with (p <0.001). Moreover; concentrations of UA in DM was 3.65 ± 0.11 mg/dl significantly lower than in control 4.56 ± 0.29 mg/dl with (p <0.001),conversely, we found that no significant change in the level of UA in RA 4.23 ± 0.66 mg/dl, compared with health subjects 4.56 ± 0.28 mg/dl. These results suggest that the feasibility to find out a new evidences for a possible relationship between these pathologies can be found.