Level of Resistin in Acute Myocardial Infarcti on Patients and its Relation to Lipid profile and Cardic Troponin I


ABSTRACT:BACKGROUND:Inflammatory responses are involved in the initiation and progression of atherosclerotic plaques.Myocardial Infarction (MI) is most commonly due to occlusion of a coronary artery following therupture of a vulnerable atherosclerotic plaque. It has been suggested that the adipose tissue mayplay an important role in mediating this chronic inflammatory process. Resistin is a cysteine-richpolypeptide that is expressed at relatively lower levels in human adipocytes but higher levels inmacrophages. Troponin is found in cardiac muscle and used for diagnosis of AMI.OBJECTIVE:To investigate the level of resistin and its effect on lipid profile and Troponin I levels in acutemyocardial infarction patients.SUBJECT AND METHODS:The study included 50 patients with AMI and forty healthy subjects as control group. In this studyresistin , lipid profile and Troponin I were measured.RESULTS:The levels of resistin, cholesterol, LDL-C were significantly elevated with (p<0.001), while HDLCwas significantly lower with (p<0.001), there was positive correlation between resistin withcholesterol, LDL-C, triglyceride and VLDL, while there was negative correlation betweenresistin with HDL in acute myocardial infarction.CONCLUSION:There was a significant increase in resistin level, in acute myocardial infarction patients and thisincrease may be related to inflammation. Resistin negatively correlated with HDL and positivelycorrelated with triglyceride and LDL this relationship makes us consider this hormone as possibleatherosclerotic factor