Study of Serum Uric Acid in a Group of Insuline Dependant Diabetes Mellitus Iraqi Patients .

Abstract

ABSTRACT:BACK ROUND:The long duration of insulin dependant diabetes mellitus eventually ends with complications like renalimpairment especially if it was badly controlled ,the first sign of renal involvement is the elevation ofserum uric acid above or near upper normal values(1).OBJECTIVE:One hundred and thirty type1 diabetic patients were enrolled in the study, they represent a selected sampleof patients who attend the Specialized Center for Endocrinology and Diabetes (Baghdad RussafaDirectorate) during the period from November 2006 to April 2007 compared with forty healthyindividuals as control group of similar age group.METHOD :The determination of fasting blood sugar ,uric acid and blood urea were done by enzymatic colorimetrictest following the Procedure performed by manufacturers.RESULTS:The level of serum uric acid and blood urea were normal in all cases of juvenile diabetes but as theduration of the disease increases the values of the serum uric acid started to raise and could be the firstsign of renal impairment in diabetic patients even before albuminuria..CONCLUSION:The concentration of uric acid in the blood is an independent marker of failing kidneys and may even playa causative role in the decline of renal function