The effect of rofecoxib and diclofenac on blood picture in male patients


Objectives: To assess the effect of roficoxib and also the effect of diclofenac as a standard nonsteroidal anti-inflammatory drug (NSAD) on complete blood picture.Methods: Complete blood picture was taken for 29 male patients on roficoxib therapy at 25 mg/day for 14-21 consecutive days. Complete blood picture was also taken for 15 male patients on roficoxib thearapy at 100 mg/day for 14-21 consecutive days. Comparison was made between measurements of blood picture before and at the end of treatment by using Students paired t-test.Results: Roficoxib or diclofenac showed no significant changes in complete blood picture in the male patients in comparison with the measurements before treatment.Conclusion: Roficoxib or diclofenac has no significant effect on blood picture in patients when used for short term with moderate doses