Analysis of Human Leukocyte Antigen Classes in Patients with Prostate Cancer and Benign Prostate Hyperplasia


ABSTRACT: BACKGROUND: Certain HLA alleles are occurring in a higher frequency in individuals with particular diseases than in the general population. METHODS: HLA-typing for class I and class II antigens expressed by cells of 40 patients with prostatic adenocarcinima (CAP) and 48 patients with benign prostatic hyperplasia (BPH), ranged in age between 48-80 years were detected by lymphocytotoxicity test using 16A, 39B, 7CW, 14DR and 4DQ antisera. RESULTS: Patients with BPH showed an increased frequency in HLA DR53, while CAP patients showed an increased frequency in HLA-A33 and HLA DR53 antigens compared to 100 healthy Kidney donor individual as a control. The increase in HLA- antigens frequency was proved by statistical analysis, relative risk (RR) and etiological function (EF) values estimation. CONCLUSION: Possibility in the future, for novel selective immunomodulatory therapeutic strategies which stimulate a clinically significant re-expression of class I protein and associated with CTL responses


HLA, Prostate cancer