Evaluation of the hematological and histopathological effects of Teucrium polium on experimental hyperthyroidism rats


Mature Albino rats of both sexes were given 5mg/kg/day carbimazole orally for 15 days for experimental induction of hyperplasia. The animals divided to four groups, G1 served as a positive control and G2, G3 and G4 treated orally with 50, 100 and 200 mg/kg/day respectively of the aqueous extract of Teucrium polium for 45 days to evaluate its effects on Hb, RBCs, differential leukocytic count and thyroid gland after 15, 30 and 45 days of treatment. The results showed a decrease in Hb and RBCs values during the first two periods and an increase during the last period of the experiment, no significant changes on the differential leukocytic count whereas T4 and T3 revealed a significant increase during the first two periods and a significant decrease during the last period. histopathological preparations of the thyroid gland revealed a remarkable amelioration on the follicular cells in which they were refilled with colloid materials and become look like normal especially in the group treated with 100mg/kg.