An evaluation of some lipid derivatives in treating irritable bowel syndrome in isolated rat intestine model

Abstract

Irritable bowel syndrome IBS remains one of the most widely distributed disorder that can interfere with human health, habitats and activities and hence causes a considerable health, social and economic burden. As a trial to solve this problem an isolated piece of rat intestine was prepaire as an in vitro model of IBS by which some lipid derivatives were assessed for their effects on intestinal strain of contraction which was recorded with a highly sensitive physiograph connected to the piece of intestine through a mechanical transducer. Malonic acid, citric acid and peppermint oil were evaluated in comparison to a standard mebeverine and amlodipine calcium reducer agents. There was a significant increase in intestinal contraction induced with malonic acid as compared with basal, amlodipine and mebeverine associated contractions (80, 50 and 50 mg respectively) at P< 0.05. however, peppermint caused no significant increase in strain whereas citric acid caused a highly significant relaxing effect down to 8 mg strain at P< 0.01 which could be implemented in human IBS. In a conclusion, citric acid showed a promising therapeutic intestinal relaxation that may be of benefit in human IBS.