Leptin in Goitrous patients

Abstract

Objective: To evaluate the relationship between serum Leptin levels and metabolic syndrome, in (obese, non obese) control subjects, untreated hypothyroid and hyperthyroid patients.Methods: A study was made on 63 goitrous patients and 25 control subjects. Body mass index (BMI) was calculated. Serum T3, T4, TSH were measured by RIA method, serum lipid profile was measured by spectrophotometric method, serum Leptin was measured by ELISA method.Results: The mean serum Leptin level was significantly higher in obese than in non obese control subjects (29.1 vs. 5.8 ngm / ml) and higher in hypothyroid patients (27.9 ngm /ml), and lowest levels in hyperthyroid patients (3.4 ngm /ml). Conclusion: Leptin reduce body weight by decreasing food intake (appetite), fat deposition and increasing energy expenditure. Serum Leptin is highly correlated with the body mass index (BMI), other indices of adiposity (lipid profile) in normal obese human and hypothyroid patients.