Serum copper levels in Non-Insulin Dependent Diabetes Mellitus


Background: The findings of previous research on the status of trace elements in diabetic patients have been controversial.A comparative study of serum copper in diabetic patients and healthy Iraqi controls is becoming important, particularly after the dietary shortage, as sequel of 13 years of sanctions.Objective: To study the difference of serum copper between the diabetic patients and healthy Iraqi people.Method: This is an outpatient-based study; it was carried out in AL-Rhasid Military Teaching Hospital during a period from March 2002 till February 2003 the study included seventy –four non insulin dependent diabetic patient (NIDDM) aged (40-62) year, forty – four from which have retinopathy and twenty – four have albuminuria (>50 mg/day) other seventy normal healthy control with comparable age (38-65) year. Blood samples were drowning fasting and the blood was left at room temperature for 10 minuets. Centrifuged 3000 rpm for 10 minuets, then serum was separated and stored at –20c0. The urine sample taken freshly, randomly on early morning and urine albumin was measured quantitatively by Lowry method, data were analyzed and compared with previous study resultConclusion: The clinical significance of serum copper in diabetes mellitus remain conflicting as well as controversial and many questions still remain unanswered but the decreased serum copper found in NIDDM in our study may merit further investigation of the relationship between copper and non-insulin dependent diabetes.