Estimation of Interferon -g and Interleukin -2 Receptor in the Rheumatoid Arthritis Sera Patients

Abstract

Rheumatoid arthritis (RA) is an inflammatory disease leading to joint destruction. Sixty patients with RA (40 females,20 males) and forty healthy individuals without inflammatory or autoimmune disease [who were used as normal subjects (20 females, 20males)] have been examined . Serum samples were collected from all patients and controls were taken during morning. Interferon (INF) -g and soluble interleukin-2 receptor (sIL-2R) levels were evaluated by using Enzyme Linked ImmunoSorbent Assay(ELISA). Results observed that, the frequency of females among RA groups(80%) with ratio of females: males(5:1) . Moreover, the mean age for RA and control groups are (38.2±7.5),(27.3±6.6) respectively .The estimation of INF-g and sIL-2R levels were highly significant in RA patients compared to the healthy control .The high level of INF-g may be due to activation of macrophage in an innate and an acquired immune response. Elevated sera sIL-2R level is considered as a sensitive marker for the immune system activity.