Correlation of HER-2/neu Oncogene Expression And Grades of Transitional Cell Carcinoma of Bladder


This study was conducted to estimate the overexpression of HER-2eu oncoprotein in human transitional cell carcinoma of bladder and to show its possible correlation to the specific pathological parameters like grade of tumor. We evaluated the available tissue blocks of 50 patients with transitional cell carcinoma who had referred to Al-diwaniya Hospital/ department of pathology in a period between January 2006 and December 2010, 32 cases were male and 18 cases were female. The mean age of the patients was 57.5 years (range from 33 to 82 years). The cases were classified according to the grading system into grade I, II, and III in 9, 24 and 17 cases respectively. From 50 cases of TCC, A total of 19 (38%) patients were positive for overexpression of HER- 2/neu oncogene, 12 (63.2%) cases of them with predominant membranous and cytoplasmic staining and 7 (36.8%) cases of them with cytoplasmic staining , there was no pure membranous staining. High histological grades of the TCC were associated with increased expression of HER-2/neu, There was 1 (11%) case of HER-2/neu-positive with a grade I tumor, 7 (29%) with grade II, and 11 (63.7%) with grade III (P =.002) There was a significant relationship in HER-2/neu over expression with high grade of TCC. Aim of the study:The aim of this study was to evaluate the relationship between HER-2/neu oncogene expression and grade of transitional cell carcinoma (TCC) of the bladder.