Effect of sitagliptin on lipid profile, Inflammation and Oxidative Stress in high cholesterol –fed male rabbits

Abstract

Back ground: Atherosclerosis is the major world wide killing disease. The most common risk factors are hyperlipidemia, diabetes, and ather factors like chronic infection and inflammation.Objective: This study was undertaken to assess the effect of sitagliptin on atherosclerosis via interfering with lipid parameter, inflammatory and oxidative pathwaysMethod: 18 local domestic male rabbits were included in this study. The animals were randomly divided into three groups: Group I rabbits fed normal chow (oxiod) diet for 12 weeks. Group II rabbits fed 1% cholesterol enriched diet. Group III rabbits fed with cholesterol enriched diet for 6 weeks, and then continued on cholesterol enriched diet and treated with Sitaglipin 125mg/kg/day orally for the next 6 weeks. Results: Treatment of rabbits with sitagliptin for 6 weeks results in a significant reduction (P<0.05) in serum level of TC, TG, hsCRP and TNFα and a significant increase (P<0.05) in serum HDL level. There was a significant reduction (P<0.05) in aortic MDA and intima-media thickness, in comparison to the rabbits in the induced untreated control group.sitagliptin treatment cause increment in aortic GSH in comparison to induced untreated group.