Total Serum Bilirubin and Related Anemia in Thalassemic Patients

Abstract

The aim of present study was to evaluate total serum bilirubin TSB (direct and indirect SB) for thalassemic patients and to verify the correlation between Hb level, age and TSB level (direct and indirect) for the same patients. To achieve this aim, Forty-three thalassemic patients (19 females & 24 male) with mean ages of 12.61±4.54 with a range of 4-22 years were enrolled. Thirty one healthy individuals (12 females & 19 males) of ages 11.55± 5.36 were enrolled as control group. The total serum bilirubin, (direct and indirect) levels in sera of patients and control group were measured by a colorimetric method. The results show a highly significant increase for TSB (P<0.001), for patients in compared with healthy control while Hb levels were decreased significantly (P<0.01) for the same patients. The linear regression analysis exhibited strong positive significant correlations for direct SB (r= 0.48, P< 0.01), indirect SB(r= 0.53, P< 0.01) with age while its negative significant relationship for direct SB (r= -0.33, P< 0.05), indirect SB(r= -0.75, P< 0.0001) with Hb levels in thalassemic patients. Conclusion, elevation of TSB in thalassemic patients and its inverse correlation with Hb consider the best indicator of the presence of anemia.

Keywords

TSB, Thalassemia, Anemia