Immunohistochemical detection of the expression of the cell adhesion molecules ICAM-1 & VCAM-1 in Pyogenic granuloma


Pyogenic granuloma is a relatively common benign vascular lesion of the oralmucosa & skin whose exact cause is unknown. The study of the expression of celladhesion molecules (ICAM-1 & VCAM-1) in oral pyogenic granuloma wasperformed.Fifteen formalin- fixed, paraffin-embedded oral pyogenic granuloma were studiedusing LSAB/HRP immunohistochemical technique.Mild to moderate expressions of cell adhesion molecules was demonstrated amongdifferent cell types of pyogenic granuloma suggesting that inflammatory response ofgingival tissue against oral antigens (gram negative bacteria) may play a major role ininflammatory neovasculairization & hence pathogenesis of pyogenic granuloma .