امتزاز دواء الميترونيدازول على سطح طين البنتونايت

Abstract

Metronidazole drug (Flagyl) is widely used in as antiprotozoal drug in bowel parasitic diseases. Bentonite in medicine used as antidiarrheal, suspending agent, and as additives. Drug overdose may treated by adsorbents especially by activated charcoal suspension to prevent further absorption, but usually it is unacceptable to drink. Hence, an attempt was made in this work to estimate the ability of bentonite as adsorbent for metronidazole overdose in vitro as a possible alternative for activated charcoal. UV-Visible spectrophotometry technique was used to follow the quantity adsorbed after incubation of bentonite with a known concentration of metronidazole solutions. The adsorption experiments were repeated at (12, 25, 37.5, and 50ºC) to measure the thermodynamical parameters (ΔHº, ΔGº, ΔSº) of the adsorption process. The results showed that, there are small amounts of metronidazole ready to adsorb on bentonite. The thermodynamic parameters values were (ΔHº=18.68 KJ.mol-1, ΔGº=-10.03 KJ.mol-1, ΔSº=96.33 J.mol-1.ºK-1). The amount of the adsorbed drug was increased as the pH of the drug solution decreased.It can be concluded that the adsorption of metronidazole on bentonite is endothermic process with low thermodynamic parameters values. The adsorption enhanced by increasing temperature and by increasing acidity of the medium.