The response to Growth Hormone Therapy in Isolated Growth Hormone Deficiency


objective: to study the response of Growth hormone therapy in children with short staturedue to isolated growth hormone deficiency.Sample: six hundred forty eight patient with short stature were enrolled in this study.Method: six hundred forty eight patient with short stature attending Central Teaching Hospitalfor children Baghdad/ Iraq, were recorded and all patients were investigated to exclude otherdisease like diabetes, hypothyroidism, celiac disease, turner syndrome, renal failure,achondroplasia,..etc. with a total of 48 patients due to these causes were excluded from the study.So the remaining patients were 600 only those exposed to our study. All children investigated forgrowth hormone basal level and after provocation by clonidine done for one time .Results: We found that the basal level of growth hormone was less 0.5 microgram (μg)/liter (L),0.5 -1 μg/liter and more than 1 μg /liter in 25%, 38% and 37% respectively in our sample, whilethe results after provocation were less than 5, 5-10 and more than 10 μg /liter in 60%, 28% and12% respectively in our sample. The effect of growth hormone in one year therapy theincrement in height was less than 4 cm in 22% of our patients, from 4-8 cm in 50%, and morethan 8 cm in 28 % and we found that the male patients were 384(64%), and the female patientswere 216(36%),with peak difference between bone age and chronological age was more than 2year for both sex and most of the patientsُ age was more than 15 years.Conclusion: Most patients with isolated growth hormone deficiency had basal growth hormonelevel 0.5 – 1μg/L, while the provocation level was less than 5μg/L and the effect of growthhormone therapy on height maximally 4-8 cm in proximately 50% of the patients and more than8 cm in 28% after one year treatment. Patients with isolated Gh deficiency showed goodresponse to therapy with growth hormone recombinant in a dose 0.1 mg /kg /day


Gh, Growth hormone