•Evaluation of Visual Evoked Potentials in the patients with Chronic Viral Hepatitis


background: The visual evoked potential (VEP) is a wave generated in the occipital cortex in response to a visual stimulation. It measures the conduction time of neuronal activity from the retina to the occipital cortex.Infection with viral hepatitis leads to a wide spectrum of clinical presentations ranging from an asymptomatic carrier state to self-limited acute or fulminate hepatitis to chronic hepatitis with progression to cirrhosis and hepatocellular carcinoma. The neurological complication is one of the extrahepatic manifestations of chronic viral hepatitis, where the involvement of the central nervous system (CNS) impairment has been reported.Objectives: To assess the visual evoked potential changes in patient with chronic viral hepatitis.Methods: Evaluation of visual evoked potentials in (27) normal subjects (18 male and 9 female) and (51) patients with documental chronic viral hepatitis disease (34 male and 17 female), divided according to type of virus to two group (30) CVHB patients, and (21) CVHC patients.Results: The VEP abnormalities in both eyes were recorded in (23.33%) of CVHB patients and (42.89%) of CVHC patients, and the VEP abnormality in one eye was recorded in (10%) of CVHB patients. The bifid W waveform of abnormal VEP was recorded on both eyes in (10%) of CVHB patients and in (19%) of CVHC patients, the bifid W waveform recorded on (10%) of CVHB patients and (4.8%) of CVHC patients.Conclusions: The abnormal VEPs and the bifid W shape are can be reported in chronic viral hepatitis patients as the early central sign of chronic viral hepatitis.